The clinical relevance of luteal phase progesterone support in true natural cycle cryopreserved blastocyst stage embryo transfers: a retrospective cohort study

Abstract Background More than 67% of all embryos transferred in the United States involve frozen-thawed embryos. Progesterone supplementation is necessary medicated cycles to luteinize endometrium and prepare it for implantation, but little data available show if this beneficial true natural cycles. We evaluated use luteal phase progesterone cryopreserved/warmed blastocyst transfers not using an ovulatory trigger. Methods Retrospective cohort study a single academic medical center. studied patients undergoing cycle cryopreserved embryo transfers. Our primary outcome measure was ongoing pregnancy rate, with other outcomes being (i.e. implantation miscarriage ectopic multifetal gestation). Categorical were analyzed utilizing Fisher’s exact test binary variables log-binomial regression produce risk ratio. Results Two hundred twenty-nine included analysis 149 receiving 80 no support. Patient demographic characteristics, quality similar between two groups. No difference seen rate (49.0% vs. 47.5%, p = 0.8738), clinical (50.3% 0.7483), positive HCG (62.4% 57.5%, 0.5965), miscarriage/abortion (5.4% 2.5%, 0.2622), (0% 1.3%, 0.3493), or gestations (7.4% 3.8%, 0.3166). Conclusion(s) The addition support did improve therefore routine practice cannot be recommended based on study, utilization should discouraged without further studies. Capsule as does pregnancies.